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單細胞測序技術服務 單細胞全轉錄組測序 |
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NGS測序技術服務 DRIP-seq |
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基因芯片技術服務 Small RNA修飾芯片 m6A單堿基分辨率芯片 mRNA&lncRNA表觀轉錄組芯片 circRNA表觀轉錄組芯片 |
NGS測序技術服務 RNA m6A甲基化測序（MeRIP Seq） |
LC-MS mRNA堿基修飾檢測 tRNA堿基修飾檢測 |
PCR技術服務 MeRIP-PCR技術服務 m6A絕對定量RT-PCR技術服務 m6A單堿基位點PCR（MazF酶切法）技術服務 |
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基因芯片技術服務 DNA甲基化芯片 DNA羥甲基化芯片 ChIP-chip |
NGS測序技術服務 DNA甲?；奏?5fc)修飾測序 DNA 5hmC 測序（化學法） DNA甲基化測序 DNA羥甲基化測序 染色質免疫共沉淀測序 |
PCR技術服務 MeDIP-qPCR hMeDIP-qPCR ChIP-qPCR |
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蛋白相對定量 TMT標記定量技術 非標定量技術 |
蛋白修飾 TMT標記定量磷酸化 非標定量磷酸化 |
RNA/蛋白-蛋白相互作用 RNA-蛋白相互作用 蛋白-蛋白相互作用 |
DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice . Journal of Hazardous Materials . 2022
Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. Journal of Hepatology . 2021
Oncogenic role of SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 positive diffuse large B-cell lymphomas. Blood . 2021
Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature communications . 2021
DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation. Science of The Total Environment . 2021
Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway. Science of The Total Environment . 2021
Calcitonin gene‐related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain. CNS Neuroscience & Therapeutics . 2021
Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain. Journal of neuroinflammation . 2021
BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response. Clinical Epigenetics . 2021
Histone demethylase KDM6A promotes somatic cell reprogramming by epigenetically regulating the PTEN and IL‐6 signal pathways . STEM CELLS . 2020
Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation . Journal of Hazardous Materials . 2019
Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment . Cell death & disease . 2019
The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4[ . Cell death & disease . 2018
The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017
A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016
Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al. Cell Metabolism, 2016.
Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011
CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell. 2012
Hypoxia Inducible Factor 2 Alpha Inhibits Hepatocellular Carcinoma Growth Through the Transcription Factor Dimerization Partner 3/ E2F Transcription Factor 1–Dependent Apoptotic Pathway. HEPATOLOGY. 2013
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. PNAS. 2013
Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. PNAS. 2013
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A. 2009
